{"id":13433,"date":"2022-11-22T08:46:56","date_gmt":"2022-11-22T08:46:56","guid":{"rendered":"https:\/\/dailytalks.org\/?p=13433"},"modified":"2022-11-22T08:46:56","modified_gmt":"2022-11-22T08:46:56","slug":"synthetic-biologics-provide-a-path-to-target-bhlh-transcription-factors","status":"publish","type":"post","link":"https:\/\/dailytalks.org\/?p=13433","title":{"rendered":"Synthetic biologics provide a path to target bHLH transcription factors"},"content":{"rendered":"<p>Nature Biotechnology, Published online: 03 November 2022; doi:10.1038\/s41587-022-01509-6The ability to target the majority of human transcription factors remains an as yet unachieved goal in chemical biology and medicine. We developed a modular, synthetic transcriptional repressor platform that recapitulates the DNA-binding properties of native basic helix-loop-helix (bHLH) domains and can block the DNA-binding functions of an important oncogenic transcription factor target&#8230;<br \/><a href=\"https:\/\/www.nature.com\/articles\/s41587-022-01509-6\" class=\"button purchase\" rel=\"nofollow noopener\" target=\"_blank\">Read More<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nature Biotechnology, Published online: 03 November 2022; doi:10.1038\/s41587-022-01509-6The ability to target the majority of human<\/p>\n","protected":false},"author":1,"featured_media":13434,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[35],"tags":[],"class_list":["post-13433","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tech"],"featured_image_urls":{"full":["https:\/\/dailytalks.org\/wp-content\/uploads\/2022\/11\/13433-synthetic-biologics-provide-a-path-to-target-bhlh-transcription-factors.png",685,238,false],"thumbnail":["https:\/\/dailytalks.org\/wp-content\/uploads\/2022\/11\/13433-synthetic-biologics-provide-a-path-to-target-bhlh-transcription-factors-150x150.png",150,150,true],"medium":["https:\/\/dailytalks.org\/wp-content\/uploads\/2022\/11\/13433-synthetic-biologics-provide-a-path-to-target-bhlh-transcription-factors-300x104.png",300,104,true],"medium_large":["https:\/\/dailytalks.org\/wp-content\/uploads\/2022\/11\/13433-synthetic-biologics-provide-a-path-to-target-bhlh-transcription-factors.png",640,222,false],"large":["https:\/\/dailytalks.org\/wp-content\/uploads\/2022\/11\/13433-synthetic-biologics-provide-a-path-to-target-bhlh-transcription-factors.png",640,222,false],"1536x1536":["https:\/\/dailytalks.org\/wp-content\/uploads\/2022\/11\/13433-synthetic-biologics-provide-a-path-to-target-bhlh-transcription-factors.png",685,238,false],"2048x2048":["https:\/\/dailytalks.org\/wp-content\/uploads\/2022\/11\/13433-synthetic-biologics-provide-a-path-to-target-bhlh-transcription-factors.png",685,238,false],"chromenews-featured":["https:\/\/dailytalks.org\/wp-content\/uploads\/2022\/11\/13433-synthetic-biologics-provide-a-path-to-target-bhlh-transcription-factors.png",685,238,false],"chromenews-large":["https:\/\/dailytalks.org\/wp-content\/uploads\/2022\/11\/13433-synthetic-biologics-provide-a-path-to-target-bhlh-transcription-factors.png",685,238,false],"chromenews-medium":["https:\/\/dailytalks.org\/wp-content\/uploads\/2022\/11\/13433-synthetic-biologics-provide-a-path-to-target-bhlh-transcription-factors-590x238.png",590,238,true]},"author_info":{"display_name":"Jonathan Jeriah","author_link":"https:\/\/dailytalks.org\/?author=1"},"category_info":"<a href=\"https:\/\/dailytalks.org\/?cat=35\" rel=\"category\">Tech<\/a>","tag_info":"Tech","comment_count":"0","_links":{"self":[{"href":"https:\/\/dailytalks.org\/index.php?rest_route=\/wp\/v2\/posts\/13433","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dailytalks.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dailytalks.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dailytalks.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dailytalks.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=13433"}],"version-history":[{"count":0,"href":"https:\/\/dailytalks.org\/index.php?rest_route=\/wp\/v2\/posts\/13433\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dailytalks.org\/index.php?rest_route=\/wp\/v2\/media\/13434"}],"wp:attachment":[{"href":"https:\/\/dailytalks.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=13433"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dailytalks.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=13433"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dailytalks.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=13433"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}