{"id":73407,"date":"2023-06-19T07:46:59","date_gmt":"2023-06-19T07:46:59","guid":{"rendered":"https:\/\/dailytalks.org\/?p=73407"},"modified":"2023-06-19T07:46:59","modified_gmt":"2023-06-19T07:46:59","slug":"selection-by-essential-gene-exon-knock-in-for-the-generation-of-efficient-cell-therapies","status":"publish","type":"post","link":"https:\/\/dailytalks.org\/?p=73407","title":{"rendered":"Selection by essential-gene exon knock-in for the generation of efficient cell therapies"},"content":{"rendered":"<p>Nature Biotechnology, Published online: 17 May 2023; doi:10.1038\/s41587-023-01819-3By linking transgene expression with that of a housekeeping gene, SLEEK (selection by essential-gene exon knock-in) enables efficient knock-in of complex cargos in a variety of clinically relevant cell types. Using SLEEK, we were able to substantially improve the tumor suppression ability and in vivo persistence of a cell therapy&#8230;<br \/><a href=\"https:\/\/www.nature.com\/articles\/s41587-023-01819-3\" class=\"button purchase\" rel=\"nofollow noopener\" target=\"_blank\">Read More<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nature Biotechnology, Published online: 17 May 2023; doi:10.1038\/s41587-023-01819-3By linking transgene expression with that of a<\/p>\n","protected":false},"author":1,"featured_media":73408,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[35],"tags":[],"class_list":["post-73407","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tech"],"featured_image_urls":{"full":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/06\/73407-selection-by-essential-gene-exon-knock-in-for-the-generation-of-efficient-cell-therapies.png",685,574,false],"thumbnail":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/06\/73407-selection-by-essential-gene-exon-knock-in-for-the-generation-of-efficient-cell-therapies-150x150.png",150,150,true],"medium":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/06\/73407-selection-by-essential-gene-exon-knock-in-for-the-generation-of-efficient-cell-therapies-300x251.png",300,251,true],"medium_large":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/06\/73407-selection-by-essential-gene-exon-knock-in-for-the-generation-of-efficient-cell-therapies.png",640,536,false],"large":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/06\/73407-selection-by-essential-gene-exon-knock-in-for-the-generation-of-efficient-cell-therapies.png",640,536,false],"1536x1536":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/06\/73407-selection-by-essential-gene-exon-knock-in-for-the-generation-of-efficient-cell-therapies.png",685,574,false],"2048x2048":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/06\/73407-selection-by-essential-gene-exon-knock-in-for-the-generation-of-efficient-cell-therapies.png",685,574,false],"chromenews-featured":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/06\/73407-selection-by-essential-gene-exon-knock-in-for-the-generation-of-efficient-cell-therapies.png",685,574,false],"chromenews-large":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/06\/73407-selection-by-essential-gene-exon-knock-in-for-the-generation-of-efficient-cell-therapies.png",685,574,false],"chromenews-medium":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/06\/73407-selection-by-essential-gene-exon-knock-in-for-the-generation-of-efficient-cell-therapies-590x410.png",590,410,true]},"author_info":{"display_name":"Jonathan Jeriah","author_link":"https:\/\/dailytalks.org\/?author=1"},"category_info":"<a href=\"https:\/\/dailytalks.org\/?cat=35\" rel=\"category\">Tech<\/a>","tag_info":"Tech","comment_count":"0","_links":{"self":[{"href":"https:\/\/dailytalks.org\/index.php?rest_route=\/wp\/v2\/posts\/73407","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dailytalks.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dailytalks.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dailytalks.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dailytalks.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=73407"}],"version-history":[{"count":0,"href":"https:\/\/dailytalks.org\/index.php?rest_route=\/wp\/v2\/posts\/73407\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dailytalks.org\/index.php?rest_route=\/wp\/v2\/media\/73408"}],"wp:attachment":[{"href":"https:\/\/dailytalks.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=73407"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dailytalks.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=73407"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dailytalks.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=73407"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}