{"id":74905,"date":"2023-06-23T22:45:25","date_gmt":"2023-06-23T22:45:25","guid":{"rendered":"https:\/\/dailytalks.org\/?p=74905"},"modified":"2023-06-23T22:45:25","modified_gmt":"2023-06-23T22:45:25","slug":"crispr-free-strand-selective-mitochondrial-dna-base-editing-using-a-nickase","status":"publish","type":"post","link":"https:\/\/dailytalks.org\/?p=74905","title":{"rendered":"CRISPR-free, strand-selective mitochondrial DNA base editing using a nickase"},"content":{"rendered":"<p>Nature Biotechnology, Published online: 22 May 2023; doi:10.1038\/s41587-023-01820-wThe fusion of a programmable transcription-activator-like effector (TALE) protein with a nickase, in conjunction with a deaminase, enables efficient and strand-selective DNA base editing. This approach has the potential to advance our understanding and treatment of diseases associated with mutations in the mitochondrial or nuclear genome&#8230;<br \/><a href=\"https:\/\/www.nature.com\/articles\/s41587-023-01820-w\" class=\"button purchase\" rel=\"nofollow noopener\" target=\"_blank\">Read More<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nature Biotechnology, Published online: 22 May 2023; doi:10.1038\/s41587-023-01820-wThe fusion of a programmable transcription-activator-like effector (TALE)<\/p>\n","protected":false},"author":1,"featured_media":74906,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[35],"tags":[],"class_list":["post-74905","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tech"],"featured_image_urls":{"full":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/06\/74905-crispr-free-strand-selective-mitochondrial-dna-base-editing-using-a-nickase.png",685,625,false],"thumbnail":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/06\/74905-crispr-free-strand-selective-mitochondrial-dna-base-editing-using-a-nickase-150x150.png",150,150,true],"medium":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/06\/74905-crispr-free-strand-selective-mitochondrial-dna-base-editing-using-a-nickase-300x274.png",300,274,true],"medium_large":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/06\/74905-crispr-free-strand-selective-mitochondrial-dna-base-editing-using-a-nickase.png",640,584,false],"large":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/06\/74905-crispr-free-strand-selective-mitochondrial-dna-base-editing-using-a-nickase.png",640,584,false],"1536x1536":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/06\/74905-crispr-free-strand-selective-mitochondrial-dna-base-editing-using-a-nickase.png",685,625,false],"2048x2048":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/06\/74905-crispr-free-strand-selective-mitochondrial-dna-base-editing-using-a-nickase.png",685,625,false],"chromenews-featured":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/06\/74905-crispr-free-strand-selective-mitochondrial-dna-base-editing-using-a-nickase.png",685,625,false],"chromenews-large":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/06\/74905-crispr-free-strand-selective-mitochondrial-dna-base-editing-using-a-nickase-685x575.png",685,575,true],"chromenews-medium":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/06\/74905-crispr-free-strand-selective-mitochondrial-dna-base-editing-using-a-nickase-590x410.png",590,410,true]},"author_info":{"display_name":"Jonathan Jeriah","author_link":"https:\/\/dailytalks.org\/?author=1"},"category_info":"<a href=\"https:\/\/dailytalks.org\/?cat=35\" rel=\"category\">Tech<\/a>","tag_info":"Tech","comment_count":"0","_links":{"self":[{"href":"https:\/\/dailytalks.org\/index.php?rest_route=\/wp\/v2\/posts\/74905","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dailytalks.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dailytalks.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dailytalks.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dailytalks.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=74905"}],"version-history":[{"count":0,"href":"https:\/\/dailytalks.org\/index.php?rest_route=\/wp\/v2\/posts\/74905\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dailytalks.org\/index.php?rest_route=\/wp\/v2\/media\/74906"}],"wp:attachment":[{"href":"https:\/\/dailytalks.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=74905"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dailytalks.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=74905"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dailytalks.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=74905"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}