{"id":87297,"date":"2023-07-30T05:44:31","date_gmt":"2023-07-30T05:44:31","guid":{"rendered":"https:\/\/dailytalks.org\/?p=87297"},"modified":"2023-07-30T05:44:31","modified_gmt":"2023-07-30T05:44:31","slug":"efficient-a-to-c-base-editing-with-high-specificity","status":"publish","type":"post","link":"https:\/\/dailytalks.org\/?p=87297","title":{"rendered":"Efficient A-to-C base editing with high specificity"},"content":{"rendered":"<p>Nature Biotechnology, Published online: 26 June 2023; doi:10.1038\/s41587-023-01866-wGenerating A-to-C transversions in specific targets via base editing technology has been challenging. By fusing an evolved alkyladenine DNA glycosylase with an engineered adenine deaminase TadA-8e variant and nickase Cas9, we have developed A-to-C base editors that generate precise and efficient A-to-C transversions in cells and in mouse embryos&#8230;<br \/><a href=\"https:\/\/www.nature.com\/articles\/s41587-023-01866-w\" class=\"button purchase\" rel=\"nofollow noopener\" target=\"_blank\">Read More<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nature Biotechnology, Published online: 26 June 2023; doi:10.1038\/s41587-023-01866-wGenerating A-to-C transversions in specific targets via base<\/p>\n","protected":false},"author":1,"featured_media":87298,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[35],"tags":[],"class_list":["post-87297","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tech"],"featured_image_urls":{"full":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/07\/87297-efficient-a-to-c-base-editing-with-high-specificity.png",685,423,false],"thumbnail":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/07\/87297-efficient-a-to-c-base-editing-with-high-specificity-150x150.png",150,150,true],"medium":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/07\/87297-efficient-a-to-c-base-editing-with-high-specificity-300x185.png",300,185,true],"medium_large":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/07\/87297-efficient-a-to-c-base-editing-with-high-specificity.png",640,395,false],"large":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/07\/87297-efficient-a-to-c-base-editing-with-high-specificity.png",640,395,false],"1536x1536":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/07\/87297-efficient-a-to-c-base-editing-with-high-specificity.png",685,423,false],"2048x2048":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/07\/87297-efficient-a-to-c-base-editing-with-high-specificity.png",685,423,false],"chromenews-featured":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/07\/87297-efficient-a-to-c-base-editing-with-high-specificity.png",685,423,false],"chromenews-large":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/07\/87297-efficient-a-to-c-base-editing-with-high-specificity.png",685,423,false],"chromenews-medium":["https:\/\/dailytalks.org\/wp-content\/uploads\/2023\/07\/87297-efficient-a-to-c-base-editing-with-high-specificity-590x410.png",590,410,true]},"author_info":{"display_name":"Jonathan Jeriah","author_link":"https:\/\/dailytalks.org\/?author=1"},"category_info":"<a href=\"https:\/\/dailytalks.org\/?cat=35\" rel=\"category\">Tech<\/a>","tag_info":"Tech","comment_count":"0","_links":{"self":[{"href":"https:\/\/dailytalks.org\/index.php?rest_route=\/wp\/v2\/posts\/87297","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dailytalks.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dailytalks.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dailytalks.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dailytalks.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=87297"}],"version-history":[{"count":0,"href":"https:\/\/dailytalks.org\/index.php?rest_route=\/wp\/v2\/posts\/87297\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dailytalks.org\/index.php?rest_route=\/wp\/v2\/media\/87298"}],"wp:attachment":[{"href":"https:\/\/dailytalks.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=87297"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dailytalks.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=87297"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dailytalks.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=87297"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}