Nature Biotechnology, Published online: 17 August 2023; doi:10.1038/s41587-023-01907-4GEARS, a machine learning model informed by biological knowledge of gene–gene relationships, effectively predicts transcriptional responses to multi-gene perturbations. GEARS can predict the effects of perturbing previously unperturbed genes and detects non-additive interactions, such as synergy, when predicting combinatorial perturbation outcomes…
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