Nature Biotechnology, Published online: 14 March 2024; doi:10.1038/s41587-024-02198-zThe underrepresentation of functional glial cells is a major challenge in brain organoid models. We developed an astroglia-enriched cortical organoid model that allows efficient generation of functional astrocytes and enables the formation of astroglial morphological subclasses with layer-specific gene expression profiles upon transplantation into the mouse brain…
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