February 8, 2025
Lipid nanoparticle-enabled gene editing in the lung via inhalation

Nature Biotechnology, Published online: 30 March 2023; doi:10.1038/s41587-023-01689-9The ability to create in vivo genomic medicines for tissues other than the liver has been impeded by difficulties in delivery. Using a high-throughput platform, we developed lipid nanoparticles that can effectively deliver mRNA and CRISPR–Cas9 gene editing tools to the lungs through intratracheal administration…
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