Nature Biotechnology, Published online: 22 May 2023; doi:10.1038/s41587-023-01820-wThe fusion of a programmable transcription-activator-like effector (TALE) protein with a nickase, in conjunction with a deaminase, enables efficient and strand-selective DNA base editing. This approach has the potential to advance our understanding and treatment of diseases associated with mutations in the mitochondrial or nuclear genome…
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