Nature Biotechnology, Published online: 01 June 2023; doi:10.1038/s41587-023-01834-4Existing methods to infer cell–cell communication from single-cell RNA-sequencing data fail to leverage the full information structure of the data, generally by operating at the level of the cell type or cluster. We describe a framework called Scriabin to perform this analysis at the level of the individual cell…
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