October 29, 2025
Solution biophysics reveals the polydisperse structure of RNA lipid nanoparticles

Nature Biotechnology, Published online: 28 October 2025; doi:10.1038/s41587-025-02909-0We applied emerging label-free biophysical techniques to map the size, composition and shape of RNA lipid nanoparticles. By linking these physical measurements to gene expression in human T cells and mice, we uncovered structure–activity relationships that guide RNA delivery…
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